LONDON: Scientists have found that sugar 'awakens' most cancers cells and makes tumours extra aggressive, according to a nine-year long research that is being hailed as a a very powerful leap forward in most cancers research.
The research undertaking performed through Vlaams Instituut voor Biotechnologie (VIB), Katholieke Universiteit Leuven (KU Leuven) and Vrije Universiteit Brussel (VUB) in Belgium clarified how the Warburg effect, a phenomenon wherein most cancers cells rapidly damage down sugars, stimulates tumour expansion.
The discovery provides evidence for a positive correlation between sugar and most cancers, which will have far- reaching impacts on tailored diets for most cancers patients.
The undertaking's focus was once the Warburg effect, or the remark that tumours convert significantly upper amounts of sugar into lactate compared to wholesome tissues.
As some of the outstanding options of most cancers cells, this phenomenon has been broadly studied or even used to come across brain tumours, amongst other packages.
But so far, it has been unclear whether or not the effect is simply a symptom of most cancers, or a purpose.
While earlier research into most cancers cell metabolism considering mapping out metabolic peculiarities, this find out about - printed within the magazine Nature Communications - clarifies the hyperlink between metabolic deviation and oncogenic efficiency in cancerous cells.
"Our research reveals how the hyperactive sugar consumption of cancerous cells leads to a vicious cycle of continued stimulation of cancer development and growth," said Johan Thevelein from VIB-KU Leuven.
"Thus, it is able to explain the correlation between the strength of the Warburg effect and tumour aggressiveness. This link between sugar and cancer has sweeping consequences," said Thevelein.
"Our results provide a foundation for future research in this domain, which can now be performed with a much more precise and relevant focus," he said.
Yeast cell research was once very important to the invention, as those cells comprise the similar 'Ras' proteins regularly present in tumour cells, which is able to purpose most cancers in mutated form.
Using yeast as a model organism, researchers tested the relationship between Ras activity and the extremely lively sugar metabolism in yeast.
"The main advantage of using yeast was that our research was not affected by the additional regulatory mechanisms of mammalian cells, which conceal crucial underlying processes," said Thevelein.
"We were thus able to target this process in yeast cells and confirm its presence in mammalian cells," he said.
The research undertaking performed through Vlaams Instituut voor Biotechnologie (VIB), Katholieke Universiteit Leuven (KU Leuven) and Vrije Universiteit Brussel (VUB) in Belgium clarified how the Warburg effect, a phenomenon wherein most cancers cells rapidly damage down sugars, stimulates tumour expansion.
The discovery provides evidence for a positive correlation between sugar and most cancers, which will have far- reaching impacts on tailored diets for most cancers patients.
The undertaking's focus was once the Warburg effect, or the remark that tumours convert significantly upper amounts of sugar into lactate compared to wholesome tissues.
As some of the outstanding options of most cancers cells, this phenomenon has been broadly studied or even used to come across brain tumours, amongst other packages.
But so far, it has been unclear whether or not the effect is simply a symptom of most cancers, or a purpose.
While earlier research into most cancers cell metabolism considering mapping out metabolic peculiarities, this find out about - printed within the magazine Nature Communications - clarifies the hyperlink between metabolic deviation and oncogenic efficiency in cancerous cells.
"Our research reveals how the hyperactive sugar consumption of cancerous cells leads to a vicious cycle of continued stimulation of cancer development and growth," said Johan Thevelein from VIB-KU Leuven.
"Thus, it is able to explain the correlation between the strength of the Warburg effect and tumour aggressiveness. This link between sugar and cancer has sweeping consequences," said Thevelein.
"Our results provide a foundation for future research in this domain, which can now be performed with a much more precise and relevant focus," he said.
Yeast cell research was once very important to the invention, as those cells comprise the similar 'Ras' proteins regularly present in tumour cells, which is able to purpose most cancers in mutated form.
Using yeast as a model organism, researchers tested the relationship between Ras activity and the extremely lively sugar metabolism in yeast.
"The main advantage of using yeast was that our research was not affected by the additional regulatory mechanisms of mammalian cells, which conceal crucial underlying processes," said Thevelein.
"We were thus able to target this process in yeast cells and confirm its presence in mammalian cells," he said.
Sugar makes cancer tumours more aggressive: Study
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October 22, 2017
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